Anisodamine Hydrobromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anisodamine Hydrobromide 是一种抗胆碱能和 α1-肾上腺素能受体拮抗剂，用于治疗急性循环性休克。

Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.

Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.

Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%. Animal Model:LPS-Induced Shock Mice Dosage:50 mg/kg Administration:I.p.Result:Markedly decreased the mortality to 20%.

6-Hydroxyhyoscyamine

Angiogenesis

Adrenergic Receptor

α1-adrenergic receptor

Metabolic Disease

Intestinal Diseases

55449-49-5

386.28

C17H24BrNO4

>98% (HPLC)

DMSO:77 mg/mL (199.34 mM)

Br.[H][C@@]12C[C@H](O)[C@@]([H])(C[C@H](C1)OC(=O)[C@H](CO)C1=CC=CC=C1)N2C

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(-20℃)

With Ice Pack

≥ 2 years